Children perinatally infected with human immunodeficiency virus (HIV) show poorer cognitive performance than uninfected peers, even with sustained virological suppression on combination antiretroviral therapy (cART). Widespread neuroimaging abnormalities, including decreased cerebral volume, decreased white matter (WM) integrity, altered neurometabolites, and regional perfusion changes suggest underlying cerebral injury1,2,3,4. While the underlying mechanisms of paediatric central nervous system (CNS) pathology in treated HIV infection remain unclear, increasing evidence suggests that HIV-associated immune and coagulation activation contribute to morbidity of multiple organ systems, including the CNS1,5.
We therefore aimed to characterize systemic and intrathecal markers of immune activation, endothelial function, and coagulation in a cohort of cART-treated perinatally HIV-infected children, and explore their relations to HIV-associated cognitive and cerebral deficits. First, we compared systemic biomarkers of immune activation, inflammation, endothelial function, and coagulation in HIV-infected children to those in matched uninfected controls. Then, we assessed whether systemic biomarker levels corresponded with intrathecal levels within the HIV-infected group. Lastly, we explored potential relationships between selected markers of immune activation, endothelial function, and previously detected cognitive deficits and magnetic resonance imaging (MRI) abnormalities.
We therefore aimed to characterize systemic and intrathecal markers of immune activation, endothelial function, and coagulation in a cohort of cART-treated perinatally HIV-infected children, and explore their relations to HIV-associated cognitive and cerebral deficits. First, we compared systemic biomarkers of immune activation, inflammation, endothelial function, and coagulation in HIV-infected children to those in matched uninfected controls. Then, we assessed whether systemic biomarker levels corresponded with intrathecal levels within the HIV-infected group. Lastly, we explored potential relationships between selected markers of immune activation, endothelial function, and previously detected cognitive deficits and magnetic resonance imaging (MRI) abnormalities.
HOW DR IMOLOA HERBAL MEDICINE HELPED ME GET RID OF MY 3 YEARS HERPES SIMPLEX VIRUS. Hello everyone my name is DONALD am from the united states i have been suffering from (HERPES) disease since 2016 and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr Imoloa and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr imoloa telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Doctor assured me that i have been cured,after some time i went to my doctor to confirmed if i have been finally healed behold it was TRUE, So friends my advise is, if you have such sickness or any other at all like hepatitis A,B,C,CANCER,HPV,HIV/AIDS,DIABETES 1 AND 2,SMALL PENIS PROBLEM ,HIGH BLOOD PRESSURE SYPHILIS, WEAK ERECTION,BREAST ENLARGEMENT AND many more ....... you can email him on drimolaherbalmademedicine@gmail.com) or whatsapp him on +2347081986098. Sir, i am indeed grateful for the help i will forever be grateful for the good work.
ReplyDelete